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Other treatments for sciatica include addressing the underlying cause, medications to relieve pain and inflammation and relax muscles, and physical therapy. Surgical procedures can sometimes be required for persisting sciatica that is caused by nerve compression at the lower spine.

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Excessive sweating can sometimes be treated with prescription antiperspirants containing aluminum chloride, anticholinergic medications such as glycopyrrolate, or with botulinum toxin (Botox) injections.

It is interesting to note that most pharmaceutical drugs are also not applied directly to the target organ. With the exception of applying the cream to the affected areas and directly injecting certain substances into the affected organ, all other drugs also act indirectly, from a distance.

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