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Chronic medical conditions also can affect the appearance of the nails. Specific color changes in the nails can be suggestive of diabetes or of liver, kidney, heart, or lung conditions. This is why doctors pay specific attention to nails during a routine physical examination.

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Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. Chronic pain typically has persisted for at least 3 months. In contrast to acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time and is often resistant to medical treatments. Chronic pain tends to interfere with the ability to perform activities of daily living and affects the quality of life.

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