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Chronic illnesses and chronic pain can also lead to a decrease in sex drive, likely through a combination of physical effects of the disease as well as the psychological stress associated with a chronic illness. Certain medications, such as some antidepressants, can also cause a reduction in sex drive.

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Current medical science uses this biochemical model of molecules, cells, tissues, organs, and systems to focus on an organized structure–function relationship of health and disease.

The amount of output current depends on the combined impedance of the electrodes, skin, and tissues. With repetitive electrical stimulation applied to the same location on the skin, the skin impedance is reduced, which could result in greater current flow as stimulation continues.

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