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The most common cause of breast discomfort is from the effects of hormones on breast tissue from the female menstrual period. Many women experience mild monthly breast pain in conjunction with their periods (menses). For some women, however, the pain can be more severe. This premenstrual breast pain is referred to as cyclic breast discomfort. The exact cause of cyclic breast discomfort has not been determined.

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Even systemic conditions can lead to dry skin. One example is hypothyroidism, which reduces the activity of the glands that produce skin secretions. Some medications, including retinoids for the skin as well as some antihistamines and diuretics, may have dry skin as a side effect.

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