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Over the years many Western physicians noticed that certain specific locations on the body seemed to respond to stimulation in a positive manner, these points became known as "Trigger Points", and were included in various treatment programs.

For migraine prevention, beta-adrenergic receptor blockers (which inhibit part of the sympathetic nerve activity) such as metoprolol, atenolol, propranol, calcium channel blockers such as flunarizine, or antidepressive agents such as amitriptyline are often prescribed. Most medications for migraine prevention would produce a general relaxation effect.

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